Tricyclic compound and use thereof

A compound selected from the group consisting of a tricyclic compound of Formula I, and a pharmaceutically acceptable salt, isomer, and solvate thereof:

• wherein
• V and W are each independently ═C(R14)—, or ═N—;
• X is —CH2—, —O—, —O—CH2—O—, —S—, —C(═O)—, —S(═O)—, —S(═O)2—, or —NR15—;
• Y is a C1-6 alkylene;
• Z is —O—, —S—, —C(═O)—, —S(═O)—, —S(═O)2—, or —NR15—;
• Ar is one of the following substituents (a) to (c),
• wherein A is —CH2—, —CF2—, —O—, —NR15—, —S—, —S(═O)—, —S(═O)2—, —C(═O)—, or —CH(OR15)—;
• B is a C1-3 alkylene;
• R1 is hydrogen, a halogen, hydroxy, amino, nitro, cyano, a C1-6 alkyl, a C1-10 alkoxy, a C1-6 alkylthio, acyl, a C1-6 alkylsulfonyloxy, a C3-12 carbocyclyl, a C3-12 carbocyclyloxy, a C3-12 carbocyclylsulfonyloxy, a 5- to 14-membered heterocyclyl, a 5- to 14-membered heterocyclyloxy, or a 5- to 14-membered heterocyclylsulfonyloxy;
• R2, R3, R4, R5, R6, and R7 are each independently hydrogen, a halogen, amino, cyano, a C1-6 alkyl, a C1-6 alkoxy, a C1-6 alkylthio, acyl, a C3-12 carbocyclyl, or a 5- to 14-membered heterocyclyl;
• R8 is hydrogen, a halogen, hydroxy, amino, nitro, cyano, a C1-6 alkyl, a C1-6 alkoxy, or a C1-6 alkylthio;
• R9 and R10 are each independently hydrogen, a halogen, hydroxy, a C1-6 alkyl, or a C1-6 alkoxy;
• R11 is hydroxy, amino, or a C1-6 alkoxy;
• R12 is hydrogen, a C1-6 alkyl, a C2-6 akenyl, a C2-6 alkynyl, a C1-6 alkoxy, a C1-6 alkoxy-C1-6 alkyl, a C3-12 carbocyclyl, or a 5- to 14-membered heterocyclyl;
• R13 is hydrogen, or a C1-6 alkyl;
• R14 is hydrogen, a halogen, amino, —CF3, nitro, cyano, a C1-6 alkyl, a C1-6 alkoxy, a C1-6 alkylthio, acyl, a C3-12 carbocyclyl, or a 5- to 14-membered heterocyclyl;
• R15 is hydrogen, or a C1-6 alkyl;
• and
• n, o, and p are each independently 0, 1, 2, or 3;
• provided that the alkylene, the alkyl, the akenyl, the alkynyl, the alkoxy, the alkylthio, the amino, the acyl, the alkylsulfonyloxy, the carbocyclyl, the carbocyclyloxy, the carbocyclylsulfonyloxy, the heterocyclyl, the heterocyclyloxy, and the heterocyclylsulfonyloxy may each independently be substituted with at least one substituent selected from the group consisting of a 4- to 7-membered heterocyclyl (unsubstituted or substituted with 1 to 3 substituents selected from the group consisting of hydroxy, a halogenated C1-6 alkyl, and a C1-6 alkoxy-carbonyl), a C3-8 cycloalkyl, hydroxy, a C1-6 alkoxy, a halogenated C1-6 alkoxy, amino, a mono- or di-C1-6 alkyl-amino, an N—C1-6 alkyl-N—C1-6 alkyl-carbonyl-amino, a C7-16 aralkyloxy, a C1-6 alkylthio, a C1-6 alkylsulfinyl, a C1-6 alkylsulfonyl, and a mono- or di-C1-6 alkyl-phosphono;
• and
• the heterocyclyl contains 1 to 4 heteroelements selected from the group consisting of N, O, S, S(═O), and S(═O)2.