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US 9,642,914 B2Granted
Photocrosslinked biodegradable hydrogel
AssigneeCase Western Reserve University
InventorsEben Alsberg, Oju Jeon
Life of this patent
Estimating the term…
Abstract
A photocrosslinked biodegradable hydrogel includes a plurality of natural polymer macromers cross-linked with a plurality of hydrolyzable acrylate cross-links. The hydrogel is cytocompatible and produces substantially non-toxic products upon degradation.
Claims35
A photocrosslinked biodegradable hydrogel comprising:
- a plurality of alginate and heparin macromers cross-linked with a plurality of hydrolyzable acrylate cross-links that can be hydrolyzed in vivo, at least one cell dispersed within or on the photocrosslinked biodegradable hydrogel, and a bioactive agent that modulates a function and/or characteristic of the cell, the hydrogel being cytocompatible and, upon degradation, producing substantially non-toxic products.
A photocrosslinked biodegradable hydrogel comprising:
- a plurality of natural polymer macromers cross-linked with a plurality of cross-links that are degradable in vivo, at least one cell dispersed within or on the photocrosslinked biodegradable hydrogel, and a bioactive agent that modulates a function and/or characteristic of the cell, the hydrogel being cytocompatible and upon degradation, producing substantially non-toxic products, wherein the cross-links are provided in at least one concentration gradient in the hydrogel to define at least one gradient release profile bioactive agents in the hydrogel.
A photocrosslinked biodegradable hydrogel comprising:
- a plurality of natural polymer macromers cross-linked with a plurality of cross-links that are degradable in vivo, a plurality of cells within or on the photocrosslinked biodegradable hydrogel, a bioactive agent that modulates a function and/or characteristic of the cells, and at least one acrylated or methacrylated attachment molecule coupling the cells to the photocrosslinked biodegradable hydrogel, the hydrogel being cytocompatible and upon degradation, producing substantially non-toxic products.
Dependencies are inferred from the claim text.