Isotopologues of isoindole derivatives
AssigneeCelgene Corporation
InventorsHon-Wah Man, Louise Michelle Cameron, Anthony Joseph Frank
Life of this patent
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Abstract
Provided herein are isoindole derivatives, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are also provided.
Claims17
A method of treating arthritis, osteoarthritis, inflammatory bowel disease, ankylosing spondylitis, rosacea, acne, pain, sarcoidosis, psoriasis, dermatitis, or chronic obstructive pulmonary disease, comprising administering to a patient a compound which is:
- or a pharmaceutically acceptable salt thereof, wherein:
- at least one of Y1-Y25 is a hydrogen that is isotopically enriched with deuterium, and the others of Y1-Y25 are non-enriched hydrogen atoms.
A method of treating psoriasis comprising administering to a patient a compound which is:
- or a pharmaceutically acceptable salt thereof, wherein:
- at least one of Y1-Y25 is a hydrogen that is isotopically enriched with deuterium, and the others of Y1-Y25 are non-enriched hydrogen atoms.
A method of treating sarcoidosis comprising administering to a patient a compound which is:
- or a pharmaceutically acceptable salt thereof, wherein:
- at least one of Y1-Y25 is a hydrogen that is isotopically enriched with deuterium, and the others of Y1-Y25 are non-enriched hydrogen atoms.
Dependencies are inferred from the claim text.