Mycobacterium tuberculosis ΔESX-3 mutants
AssigneeAlbert Einstein College of Medicine
InventorsWilliam R. Jacobs, JoAnn M. Tufariello
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Abstract
Isolated mutant Mycobacterium tuberculosis bacteria comprising a deletion in the ESAT-6 gene cluster region 3 (esx-3 region) are provided, as well as compositions comprising such, methods of production thereof and methods of use thereof.
Claims5
A method of eliciting an immune response in a subject comprising administering to the subject a composition comprising a non-naturally occurring mutant Mycobacterium tuberculosis bacterium, wherein the mutation of the mutant M. tuberculosis consists of a deletion of the entire esx-3 region of a genome thereof, in an amount effective to elicit an immune response.
Dependencies are inferred from the claim text.