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AssigneesTianjin University, Hainan Lingkang Pharmaceutical Co., Ltd
InventorsHongxun Hao, Linggang Tao, Zhihong Sun, Baohong Hou, Jun Lv, Qiuxiang Yin, Yongli Wang, Junbo Gong, Chuang Xie, Ying Bao
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A novel crystalline form of Cefathiamidine compound and its preparation method, characterizing in its X-ray powder diffraction pattern and differential scanning calorimetry thermogram. Dissolving Cefathiamidine compound with a purity of 98% or higher in a solvent at a temperature of 30˜45° C. to form a solution, whose concentration is controlled within 0.05˜0.2 g/mL, and then adding a solventing-out agent to the solution, wherein the amount of the solventing-out agent is 3˜5 times (in volume) of that of the solvent; followed by cooling the solution down to 0˜10° C. at a rate of 0.2˜1° C./min; continuing to stir for 1˜3 hours, and separating the obtained solid-liquid suspension to provide a novel crystalline form of Cefathiamidine compound after drying.
A crystallized Cefathiamidine, characterized in that, it has an X-ray powder diffraction pattern comprising characteristic diffraction peaks (expressed in degrees 2θ) at 7.26°±0.2°, 8.08°±0.2°, 10.38°±0.2°, 12.64°±0.2°, 13.96°±0.2°, 14.52°±0.2°, 16.60°±0.2°, 19.22°±0.2°, 20.04°±0.2°, 21.14°±0.2°, 21.84°±0.2°, and 22.74°±0.2°.
A method for preparing a crystallized Cefathiamidine, characterized in that:
Dependencies are inferred from the claim text.