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US 9,636,370 B2Granted
AAV vectors targeted to oligodendrocytes
AssigneeThe University of North Carolina at Chapel Hill
InventorsThomas McCown, Steven Gray
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Abstract
The invention relates to chimeric AAV capsids targeted to oligodendrocytes, nucleic acids encoding the capsids, virus vectors and particles comprising the same, methods of producing the vectors, and methods of using the vectors to target oligodendrocytes. The invention further relates to methods of treating a disorder associated with oligodendrocyte dysfunction using the vectors.
Claims9
An adeno-associated virus (AAV) capsid comprising the amino acid sequence of one of SEQ ID NOS:2-4, wherein 25 or fewer amino acids are substituted, deleted, and/or inserted.
Dependencies are inferred from the claim text.