Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same
AssigneesWashington University, Sage Therapeutics, Inc.
InventorsDouglas Covey, Albert Jean Robichaud
Life of this patent
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Abstract
The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.
Claims18
A compound of Formula (I-g):
- or a pharmaceutically acceptable salt thereof;
- wherein:
- R1 is selected from (C1-C4 alkyl)-O, spirooxirane, cyano, ═O, nitro, (C1-C4 alkyl)C(O), and HO(C1-C4 alkyl)C(O);
- R2 is ═O, H, or ORa, where Ra is selected from H, optionally substituted C1-C4 alkyl, or optionally substituted aryl, with the proviso that when R2 is ═O, R8 is not present;
- R3 is H, optionally substituted C1-C4 alkyl, optionally substituted C2-C4 alkenyl, optionally substituted C2-C4 alkynyl, or optionally substituted aryl;
- Rb is methyl;
- R8, when present, is H or optionally substituted C1-C4 alkyl;
- - - - denotes an optional, additional C—C bond, resulting in a C═C bond between C16-C17, with the proviso that when present, the R1 is not ═O or spirooxirane.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound of formula:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
A pharmaceutical composition comprising a compound of formula:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
A pharmaceutical composition comprising a compound of formula:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
A pharmaceutical composition comprising a compound of formula:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
A pharmaceutical composition comprising a compound of formula:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
A pharmaceutical composition comprising a compound of formula:
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.