US 9,630,838 B2 · Ferrofluids stable in neutral media and modified ferrofluids modifies obtained by modification of the surface of the particles of said ferrofluids

Abstract

The invention relates to aqueous dispersions, comprising particles based on a magnetic iron oxide with dimensions of ≦20 nm, the surface of which is modified by the grafting of aminated groups R with a covalent bonding to the surface of said particles, wherein the isoelectronic point of particles with such a modified surface is ≧10. The invention further relates to a method for production of said aqueous suspensions and a method for modification of the surface of the particles present in said dispersions, in particular, by the immobilisation of polysaccharides such as dextrans, particularly for the formulation of magnetic compositions which may be administered in vivo and in particular for the formulation of injectable compositions of contrast agents for MRI.

Claims41

Dependent claims

An aqueous dispersion comprising particles (p) based on a magnetic iron oxide,

said particles having dimensions of less than or equal to 20 nm, and
a surface of said particles being modified by a grafting of aminated groups (R) covalently bonded to the surface of the particles,
wherein, the aminated groups (R) are selected from the group consisting of:
—(CH2)3—NH2;
—(CH2)4—NH2;
—(CH2)3—NH—(CH2)2—NH2;
—(CH2)3—NH—(CH2)6—NH2;
—(CH2)3—NH—CH(CH)3CH2—NH2;
—(CH2)3—NH—(CH2)2—NH—(CH2)2—NH2;
and
the isoelectric point of the particles with the surface so modified is greater than or equal to 10.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/558,069Filed 13 May 2004

Priority

FR 03 0627923 May 2003

Published

US 2007/0090323 A126 Apr 2007

Granted

25 Apr 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61K 49/1848
Having a magnetic core coated or functionalised with a small organic molecule: the small organic molecule being a silane
A61K 49/186
The organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA: the…
A61K 49/1863
Having a magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule:…
B82Y 5/00
Nanobiotechnology or nanomedicine

Ferrofluids stable in neutral media and modified ferrofluids modifies obtained by modification of the surface of the particles of said ferrofluids

Life of this patent

Ferrofluids stable in neutral media and modified ferrofluids modifies obtained by modification of the surface of the particles of said ferrofluids

Life of this patent

Abstract

Claims41