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US 9,629,932 B2Granted
Photodynamic diagnosis, formulations usable as photosensitizers for this purpose, method for the production and use thereof
AssigneeSanochemia Pharmazeutika AG
InventorsStefan Welzig, Beate Kalz, Jozsef Gungl, Klaus Gerdes, Werner Frantsits, Christina Abrahamsberg
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Abstract
In the early detection of cancer, in particular bladder cancer, a photodynamic diagnosis uses, as a photosensitizer, a formulation that contains sodium hypericinate that is bonded to polyvinylpyrrolidone or complexed with polyvinylpyrrolidone.
Claims6
A method for photodynamic diagnosis of tumors, comprising:
- photosensitizing with a photosensitizer that is a stable complex or a stable compound of a sodium or potassium salt of hypericin and a polymeric complexing agent selected from the group consisting of polyethylene glycol and poly-N-vinyl amide, the photosensitizer containing 0.225 mg of hypericin
- wherein the photosensitizer is obtained from a lyophilizate obtained from a solution of the sodium or potassium metal salt of hypericin, the polymeric complexing agent and a buffer system comprising a phosphate buffer or a citric acid buffer.
Dependencies are inferred from the claim text.