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US 9,624,463 B2Granted
Filtration system and use thereof
AssigneeCharles River Laboratories, Inc.
InventorsNorman R. Wainwright, Dana M. Nutter, Eric Stimpson, Al Fuchs, Thomas Preidel
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Abstract
The invention relates to a filtration system for use in a method of determining the presence and/or amount of cells, for example, viable cells, in a liquid sample, and to methods of using and manufacturing such a filtration system. The filtration system includes a cup with an upper portion and a ring portion, where the ring portion is separably coupled to the upper portion.
Claims24
A cell capture system for receiving a fluid sample, the system comprising:
- (a) a cup comprising:
- (i) an upper portion,
- (ii) a ring having a periphery, wherein the upper portion is separably coupled to the ring by a frangible connection comprising a circumferential groove that defines a parting plane between the upper portion and the ring so that the upper portion can be separated from the ring upon manual application by a user of a rotational force sufficient to break the frangible connection, and
- (iii) a fluid permeable membrane attached to the periphery to produce a fluidic seal between the membrane and the ring, wherein a portion of the membrane is adapted to retain cells thereon;
- and
- (b) a base comprising a wall configured to receive the ring, the periphery of the ring and the wall of the base further comprising a plurality of protrusions and a corresponding plurality of notches, which when engaged with one another resist rotation of the cup relative to the base when the rotational force is created by the user to break the frangible connection.
3 more elements
Dependencies are inferred from the claim text.