Antibody recognizing N-domain of midkine
AssigneeCellmid Limited
InventorsSadatosi Sakuma, Maria Halasz, Darren Jones
Life of this patent
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Abstract
The present disclosure relates to isolated or recombinant proteins, such as antibodies, which inhibit or reduce the function of midkine (hereinafter, referred to as “MK”) for use in the treatment or prevention of midkine-related disorders.
Claims11
A method for treating a midkine-related disorder comprising administering to a subject in need thereof an isolated or recombinant protein comprising an antigen binding domain of an antibody which specifically binds to an epitope located within the N-domain of midkine (MK) as defined by amino acid residues 1-61 of SEQ ID NO:2, wherein the isolated or recombinant protein comprises
- a heavy chain variable domain comprising heavy chain CDR sequences CDR1, CDR2 and CDR3 as shown in SEQ ID NO:7, SEQ ID NO:8 and SEQ ID NO:9 respectively;
- and
- a light chain variable domain comprising light chain CDR sequences CDR1, CD2 and CDR3 as shown in SEQ ID NO:10, SEQ ID NO:11 and SEQ ID NO:12 respectively;
- wherein the protein inhibits or reduces a function of midkine, wherein the midkine-related disorder is cancer, inflammation, multiple sclerosis, or post-laparotomy adhesions.
A method for treating a midkine-related disorder comprising administering to a subject in need thereof an isolated or recombinant protein comprising an antigen binding domain of an antibody which specifically binds to an epitope located within the N-domain of midkine (MK) as defined by amino acid residues 1-61 of SEQ ID NO:2, wherein the isolated or recombinant protein comprises
- a heavy chain variable domain comprising SEQ ID NO:5 or a sequence exhibiting 95% or greater identity thereto;
- and
- a light chain variable domain comprising SEQ ID NO:6 or a sequence exhibiting 95% or greater identity thereto, wherein the protein inhibits or reduces a function of midkine, wherein the midkine-related disorder is cancer, inflammation, multiple sclerosis, or post-laparotomy adhesions.
Dependencies are inferred from the claim text.