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US 9,624,276 B2Granted
Peptidic chimeric antigen receptor T cell switches and uses thereof
AssigneeThe California Institute for Biomedical Research
InventorsTravis Young, Chanhyuk Kim, Peter G. Schultz
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Abstract
Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.
Claims25
A kit comprising:
- a. a chimeric antigen receptor-effector cell switch comprising:
- i. a peptidic antigen comprising a yeast transcription factor GCN4 peptide that binds to and activates an anti-GCN4 chimeric antigen receptor on an effector cell;
- said GCN4 peptide comprising a portion of SEQ ID NO:
- 2 that is at least 12 amino acids;
- and
- ii. a targeting moiety that binds a cell surface molecule on a target cell;
- and
- b. a chimeric antigen receptor-effector cell comprising an anti-GNC4 chimeric antigen receptor that binds to the peptidic antigen of the chimeric antigen receptor-effector cell switch.
5 more elements
Dependencies are inferred from the claim text.