Mutated structural protein of a parvovirus
AssigneesMediGene AG, Ludwig-Maximilians-Universitaet, Universitaet Zu Koeln
InventorsKerstin Lux, Hildegard Buening, John Nieland, Jorge Boucas, Mirko Ritter, Markus Hoerer, Luca Perabo, Michael Hallek
Life of this patent
Estimating the term…
Abstract
The present invention is related to a structural protein of a parvovirus with an amino acid insertion at the insertion site I-453, a library comprising the protein, a multimeric structure comprising the protein, a nucleic acid encoding the protein, a vector, virus, or cell comprising the nucleic acid, a process for the preparation of the protein, a medicament comprising the protein, nucleic acid, or multimeric structure as well as methods and uses involving the protein, nucleic acid, or multimeric structure.
Claims16
A structural protein of a parvovirus which comprises a first amino acid insertion of one or more amino acids into I-453, and a second amino acid insertion of one or more amino acids into I-587, wherein the first amino acid insertion is directly C-terminal of amino acid G453 and the second amino acid insertion is directly C-terminal of amino acid N587 in the sequence of AAV-2 or the corresponding amino acids of any other parvovirus, wherein the first amino acid insertion and the second amino acid insertion are each a tolerogen-derived epitope.
Dependencies are inferred from the claim text.