Nucleoside kinase bypass compositions and methods

A compound having Formula I:

• wherein,
• R1 is H, OH, C1-6 alkyl, C1-6 alkyl substituted with one or more hydroxyl groups, C1-6 alkyl substituted with one or more halo groups, C1-6 alkenyl, C1-6 alkenyl substituted with one or more hydroxyl groups, C1-6 alkenyl substituted with one or more halo groups, C1-6 alkynyl, C1-6 alkynyl substituted with one or more hydroxyl groups, C1-6 alkynyl substituted with one or more halo groups, C1-6 alkoxyl, C1-6 alkoxyl substituted with one or more hydroxyl groups, C1-6 alkoxyl substituted with one or more halo groups, aryl, heteroaryl, heterocyclyl, —NHC1-6 alkyl, arylC1-6 alkyl, heteroarylC1-6 alkyl, heterocyclylC1-6 alkyl, guanidinyl, C1-6alkylC(O)O—, arylC(O)O—, heterocyclylC(O)O—, O-propargyl, S-propargyl, O-allyl, or S-allyl;
• R4 is S or O;
• each R2, R3, R5, R6, R7 and R8 is independently halo or R1 as above;
• R9 is O-phenyl, O-naphthyl, or O-benzyl any of which can be substituted with one or more halo groups;
• or NH-benzyl, NHR12 or N(R12)2, wherein each R12 is independently H, C1-10 alkyl, or C1-10 alkyl substituted with one or more halo groups;
• R10 is S or O;
• and
• NUC is selected from the group consisting of: