Hydroxyl compounds and compositions for cholesterol management and related uses
AssigneeEsperion Therapeutics, Inc.
InventorsJean-Louis H. Dasseux, Carmen D. Oniciu
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AssigneeEsperion Therapeutics, Inc.
InventorsJean-Louis H. Dasseux, Carmen D. Oniciu
Estimating the term…
The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
A method of inhibiting sterol synthesis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a compound of formula I and a pharmaceutically acceptable vehicle, to thereby inhibit sterol synthesis in the patient, wherein formula I is represented by:
Dependencies are inferred from the claim text.