Modified hyaluronate hydrophilic compositions, coatings and methods
AssigneeLake Region Manufacturing, Inc.
InventorPeter Anthony Edwards
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Abstract
This invention relates to hydrophilic polymer compositions and a preferred application therefore, viz., hydrophilic medical device coatings. The hyaluronic acid hyaluronon by itself or modified as described herein advantageously reacts with compositions disclosed in U.S. Pat. No. 7,776,956 to produce hydrophilic compositions and coatings particularly useable with medical devices.
Claims28
An HA-based composition, comprising the reaction product of:
- a) an HA-compound selected from the group consisting of a hyaluronic acid, a hyaluronate, a hyaluronan, and salts thereof;
- and
- b) a water dispersible epoxy urethane (glycidyl carbamate) of formula I or II, or a self-crosslinked derivative thereof:
- wherein:
- i) n ranges from 1 to 50;
- ii) R2 is independently an optionally substituted divalent C1-C15 alkyl, an optionally substituted divalent C13-C15 cycloalkyl, or a group selected from:
- and
- iii) R3 is independently an optionally substituted C1-C15 alkyl.
An HA-based composition, comprising the reaction product of:
- a) an HA-compound selected from the group consisting of a hyaluronic acid, a hyaluronate, a hyaluronan, and salts thereof coupled to polyalkylene glycol end-capped isocyanate;
- and
- b) a water dispersible epoxy urethane (glycidyl carbamate) of formula I or II:
- c) wherein:
- i) n ranges from 1 to 50;
- ii) R2 is independently an optionally substituted divalent C1-C15 alkyl, an optionally substituted divalent C3-C15 cycloalkyl, or a group selected from:
- and
- iii) R3 is independently an optionally substituted C1-C15 alkyl.
An HA-based composition, consisting essentially of the reaction product of:
- a) an HA-compound selected from the group consisting of a hyaluronic acid, a hyaluronate, a hyaluronan, and salts thereof;
- and
- b) a water dispersible epoxy urethane (glycidyl carbamate) of formula I or II, or a self-crosslinked derivative thereof:
- wherein:
- i) n ranges from 1 to 50;
- ii) R2 is independently an optionally substituted divalent C1-C15 alkyl, an optionally substituted divalent C13-C15 cycloalkyl, or a group selected from:
- and
- iii) R3 is independently an optionally substituted C1-C15 alkyl.
An HA-based composition, consisting essentially of the reaction product of:
- a) an HA-compound selected from the group consisting of a hyaluronic acid, a hyaluronate, a hyaluronan, and salts thereof coupled to polyalkylene glycol end-capped isocyanate;
- and
- b) a water dispersible epoxy urethane (glycidyl carbamate) of formula I or II:
- c) wherein:
- i) n ranges from 1 to 50;
- ii) R2 is independently an optionally substituted divalent C1-C15 alkyl, an optionally substituted divalent C3-C15 cycloalkyl, or a group selected from:
- and
- iii) R3 is independently an optionally substituted C1-C15 alkyl.
Dependencies are inferred from the claim text.