Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same
Assignee3M Innovative Properties Company
InventorsYing Zhang, Percy T. Fenn, Peter R. Johnson
Life of this patent
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Abstract
A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.
Claims18
A medical device comprising:
- an array of microneedles;
- and
- a coating on or within at least a portion of the microneedles, wherein the coating comprises:
- a peptide therapeutic agent;
- and
- an amino acid,
- wherein the peptide therapeutic agent and the amino acid both have a net positive charge, and
- wherein the peptide therapeutic agent is a parathyroid hormone-related protein analogue represented by formula [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.
A method of making a medical device comprising microneedles, the method comprising:
- providing an aqueous composition comprising a peptide therapeutic agent, an amino acid, and a buffer, wherein the peptide therapeutic agent and the amino acid both have a net positive charge in the aqueous composition;
- contacting the microneedles with the aqueous composition;
- and
- volatilizing a portion of the aqueous composition to provide a coating on at least a portion of the microneedles, wherein the coating comprises at least the peptide therapeutic agent and the amino acid, and wherein the peptide therapeutic agent is a parathyroid hormone-related protein analogue represented by formula [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.
A method of stabilizing a peptide therapeutic agent on or within an array of microneedles, the method comprising incorporating the peptide therapeutic agent and an amino acid on or within the array of microneedles, wherein the peptide therapeutic agent and the amino acid both have a net positive charge, and wherein the peptide therapeutic agent is a parathyroid hormone-related protein analogue represented by formula [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.
Dependencies are inferred from the claim text.