Back to results
US 9,617,340 B2Granted
Compositions and methods for diagnosing and treating cancer
AssigneeOncoMed Pharmaceuticals, Inc.
InventorsAustin Gurney, Aaron Ken Sato, Maureen Fitch-Bruhns
Life of this patent
Estimating the term…
Abstract
Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of treating cancer, the method comprising administering an anti-Notch antibody in an amount effective to inhibit tumor growth.
Claims18
An isolated antibody that specifically binds to a glutamate ligand binding region of two or more human Notch receptors, wherein:
- a) the glutamate ligand binding region of human Notch1 is the amino acid sequence of SEQ ID NO:
- 21;
- b) the glutamate ligand binding region of human Notch2 is the amino acid sequence of SEQ ID NO:
- 22;
- c) the glutamate ligand binding region of human Notch3 is the amino acid sequence of SEQ ID NO:
- 23;
- and
- d) the glutamate ligand binding region of human Notch4 is the amino acid sequence of SEQ ID NO:
- 24.
6 more elements
Dependencies are inferred from the claim text.