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US 9,616,105 B2Granted
Agent for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory T cells
AssigneeAiCuris GmbH & Co. KG
InventorsDaniela Paulsen, Nina Brunner, Dorothy Bray
Life of this patent
Estimating the term…
Abstract
The present invention relates to an agent for the treatment and/or prophylaxis of an autoimmune disease, an agent for the formation of regulatory T cells (TReg) in an organism and various methods in which the agents according to the invention are used.
Claims15
A method for the treatment and/or prevention of the worsening of an autoimmune disease in an organism, the method comprising:
- (a) administering a mutein of human interleukin-2 (hIL-2 mutein) to the organism, wherein said hIL-2 mutein has an amino acid substitution in at least one of the positions 20, 88 or 126, numbered in accordance with the hIL-2 wild type sequence as set forth in SEQ ID NO:
- 1;
- and
- (b) if necessary, repeating step (a),
- wherein the autoimmune disease is type I diabetes, multiple sclerosis, or systemic lupus erythematosus, and wherein the administration induces regulatory T cells in the organism.
2 more elements
A method for the treatment and/or prevention of the worsening of an autoimmune disease in an organism, the method comprising:
- (a) administering a mutein of human interleukin-2 (hIL-2 mutein) to the organism, wherein said hIL-2 mutein has an amino acid substitution in at least one of the positions 20, 88 or 126, numbered in accordance with the hIL-2 wild type sequence as set forth in SEQ ID NO:
- 1;
- and
- (b) if necessary, repeating step (a),
- wherein the autoimmune disease is type I diabetes or multiple sclerosis.
2 more elements
Dependencies are inferred from the claim text.