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US 9,616,032 B2Granted
Sustained-release nucleic acid matrix compositions
AssigneePolypid Ltd.
InventorsNoam Emanuel, Yosef Rosenfeld
Life of this patent
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Abstract
There are provided compositions for extended release of a nucleic acid agent, comprising a lipid-saturated matrix formed with a biodegradable polymer. Also provided are methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of the nucleic acid agent.
Claims20
A substrate at least a portion of the surface of which is coated by a matrix composition comprising:
- a. a biocompatible polymer comprising a polyester;
- b. a first lipid component comprising at least one lipid having a polar group;
- c. a second lipid component comprising at least one phospholipid having fatty acid moieties of at least 14 carbons;
- d. at least one nucleic acid based agent;
- and
- e. polyethylene glycol (PEG);
- wherein when maintained in an aqueous environment the matrix composition provides sustained and/or controlled release of the nucleic acid based agent.
4 more elements
The coated substrate of claim l, wherein the polyester is selected from the group consisting of PLA (polylactic acid), PGA (poly glycolic acid) PLGA (Poly (lactic co glycolic acid) and combinations thereof.
Dependencies are inferred from the claim text.