Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
AssigneeACEA Biosciences, Inc.
InventorsNan Li, Xiaobo Wang, Yama A. Abassi, Biao Xi, Wen Fu Zhang, Xiao Xu
Life of this patent
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Abstract
A method of determining one or more beating parameters for use in cardiomyocyte beating analysis including: providing a cell analysis device including wells, each well including a sensor capable of monitoring beating of cardiomyoctes in millisecond time resolution; adding cardiomyocytes to the wells; monitoring the beating of the cardiomyocytes in millisecond time resolution to obtain a plurality of beating measurements; and calculating one or more beating parameters from the plurality of beating measurements.
Claims18
A method of determining a beating parameter for cardiomyocyte beating analysis, comprising:
- a) providing a cell analysis device comprising wells, each well comprising a sensor that measures cell-substrate impedance to monitor beating of cardiomyoctes in millisecond time resolution;
- b) adding cardiomyocytes to the wells;
- c) monitoring cell-substrate impedance of beating cardiomyocytes in millisecond time resolution to obtain a plurality of beating measurements;
- and
- d) calculating one or more beating parameters from the plurality of beating measurements.
Dependencies are inferred from the claim text.