Biodegradable photoluminescent polymers
AssigneeBoard of Regents, The University of Texas System
InventorsJian Yang, Santosh Gautam
Life of this patent
Estimating the term…
Abstract
Biodegradable photoluminescent polymer (BPLP) which comprises an oligomer synthesized from a multifunctional monomer, a diol, and an amino acid by reacting (i) a multifunctional monomer comprising citric acid or triethyl citrate with (ii) a diol to form a reaction product, and further reacting the reaction product with (iii) an amino acid, wherein the amino acid is linked as a side group to the oligomer backbone. The BPLP of the present invention poses tunable fluorescence emission characteristics and are cell-compatible and biodegradable. The BPLP can serve as both implant materials and bioimaging probes.
Claims20
A polymer composition comprising:
- an oligomer synthesized from monomers comprising (i) a multifunctional monomer comprising citric acid or triethyl citrate, (ii) a diol, and (iii) an amino acid, wherein the amino acid is linked as a side group to the oligomer backbone.
A composition comprising:
- an oligomer synthesized from monomers comprising (i) a multifunctional monomer comprising citric acid or triethyl citrate, (ii) a diol, (iii) an amino acid, and (iv) a di-isocyanate wherein the amino acid is linked as a side group to the oligomer backbone.
A method of making a crosslinked urethane-doped biodegradable photoluminescent polyester (CUBPLP) comprising:
- mixing (i) a multifunctional monomer comprising citric acid or triethyl citrate and (ii) a diol to form a mixture;
- raising the temperature of the mixture to melt the mixture;
- lowering the temperature of the mixture with stirring to form an oligomer;
- adding an amino acid to the oligomer with stirring to form a pre-BPLP-amino acid;
- purifying the pre-BPLP-amino acid;
- dissolving the purified pre-BPLP-amino acid to form a solution;
- adding a di-isocyanate to the pre-BPLP-amino acid solution to form a pre-CUBPLP (UBPLP);
- casting a film of the pre-CUBPLP (UBPLP);
- and
- drying the pre-CUBPLP (UBPLP) film to obtain the CUBPLP.
Dependencies are inferred from the claim text.