Drug delivery particle and method for producing the same
AssigneeNational Center of Neurology and Psychiatry
InventorsTakashi Okada, Shin'ichi Takeda, Hiromi Kinoh
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Abstract
An object of the present invention is to develop and provide a method for conveniently introducing a nucleic acid, a peptide, and/or a low-molecular-weight compound into an empty capsid with viral early infection activities kept. The present invention provides a method for producing a drug delivery particle, comprising the steps of: mixing an empty capsid or an empty particle with a drug including a nucleic acid, a peptide, and/or a low-molecular-weight compound in a solution comprising 0.1 to 20% of a surfactant; and keeping the obtained mixed solution at −5 to 50° C. to introduce the drug into the empty capsid or the empty particle.
Claims7
A method for producing a drug delivery particle comprising a capsid or an enveloped particle comprising a drug, comprising the steps of:
- (a) mixing an empty capsid or an empty enveloped particle with the drug in a solution comprising 0.1 to 20% of a surfactant;
- and
- (b) keeping a temperature of the mixed solution at −5 to 50° C. for 5 to 120 minutes to introduce the drug into the empty capsid or the empty enveloped particle.
Dependencies are inferred from the claim text.