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US 9,605,243 B2Granted
Markers of definitive endoderm
AssigneeViaCyte, Inc.
InventorsKevin Allen D'Amour, Alan D. Agulnick, Emmanuel Edward Baetge
Life of this patent
Estimating the term…
Abstract
Disclosed herein are reagent-cell complexes comprising one or more definitive endoderm cells. Also described herein are compositions for detecting definitive endoderm. Method of enriching, isolating and/or purifying definitive endoderm cells are also disclosed.
Claims2
An in vitro method of producing cells which express thyroid transcription factor 1 (TITF1) from mammalian definitive endoderm cells comprising the steps of:
- (i) culturing mammalian definitive endoderm cells with an effective amount of Wnt3a for at least 7 days,
- (ii) enriching for cells which express TITF1.
Dependencies are inferred from the claim text.