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US 9,605,055 B2Granted
Anti-CD100 antibodies and methods of using the same
AssigneeVaccinex, Inc.
InventorsErnest S. Smith, Terrence Lee Fisher
Life of this patent
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Abstract
Compositions and methods are provided for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers. In particular, anti-CD100 monoclonal antibodies have been developed to neutralize CD100.
Claims11
A method for treating a cancer in an animal in need of treatment, comprising administering to said animal a composition comprising:
- an isolated antibody or antigen-binding fragment thereof that specifically binds to CD100, wherein the antibody or fragment thereof comprises a VH polypeptide comprising VH-CDR1, VH-CDR2, and VH-CDR3 amino acid sequences comprising SEQ ID NOs:
- 6, 7, and 8, respectively, and a VL polypeptide comprising VL-CDR1, VL-CDR2, and VL-CDR3 amino acid sequences comprising SEQ ID NOs:
- 14, 15, and 16, respectively;
- and a pharmaceutically acceptable carrier.
1 more element
Dependencies are inferred from the claim text.