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US 9,604,909 B2Granted
L-ornithine phenyl acetate and methods of making thereof
AssigneeOcera Therapeutics, Inc.
InventorsKeith Anderson, Jim Behling, Christine Henderson Dougan, Stephen William Watt, Peter Manini, Attilia Figini
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Abstract
Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
Claims4
A process for making L-ornithine phenyl acetate salt comprising:
- increasing the pH value of a solution comprising an L-ornithine salt at least until an intermediate salt precipitates, wherein said intermediate salt is not an L-ornithine salt;
- isolating the intermediate salt from said solution;
- intermixing phenyl acetic acid with said solution;
- and
- isolating L-ornithine phenyl acetate salt from said solution.
2 more elements
Dependencies are inferred from the claim text.