Use of human biliverdin reductase and fragments thereof for the treatment of protein kinase C-delta and ERK related conditions
AssigneeUniversity of Rochester
InventorMahin D. Maines
Life of this patent
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Abstract
The present invention is directed to methods of modulating PKC-δ activity and PKC-δ/ERK complex activity in cells via biliverdin reductase. Methods and compositions for diagnosing and treating a PKC-δ and PKC-δ/ERK complex related condition are also disclosed.
Claims11
An isolated peptide consisting of the amino acid sequence selected from the group consisting of GL [K/R] [K/R]N[K/R][F/Y/W]L[S/T][F/Y/W][K/R/H][F/Y/W][K/R][S/T] (SEQ ID NO :44) and myristolated SEQ ID NO:
- 44.
An isolated peptide consisting of an amino acid sequence selected from the group consisting of [K/R][K/R]N[K/R]Y[L/I]S[F/W] (SEQ ID NO:
- 18) and myristolated SEQ ID NO:
- 18.
An isolated peptide consisting of the amino acid sequence selected from the group consisting of FXFPXF[S/T]G (SEQ ID NO:
- 33) and myristolated SEQO ID NO:
- 33, wherein X at amino acid positions 2 and 5 is any amino acid.
Dependencies are inferred from the claim text.