Monoclonal antibody binding specifically to DLL4 and use thereof

A monoclonal antibody that binds specifically to human delta-like ligand 4 (DLL4) to inhibit an interaction between human delta-like ligand 4 (DLL4) and Notch receptor,

• wherein the monoclonal antibody comprises:
• a heavy chain variable region comprising the heavy chain CDR1 amino acid sequence set forth in SEQ ID NO:
• 2;
• the heavy chain CDR2 amino acid sequence set forth in SEQ ID NO:
• 3;
• and the heavy chain CDR3 amino acid sequence set forth in SEQ ID NO:
• 4;
• and a light chain variable region comprising the light chain CDR1 amino acid sequence set forth in SEQ ID NO:
• 16;
• the light chain CDR2 amino acid sequence set forth in SEQ ID NO:
• 17;
• and the light chain CDR3 amino acid sequence set forth in SEQ ID NO:
• 18;
• a heavy chain variable region comprising the heavy chain CDR1 amino acid sequence set forth in SEQ ID NO:
• 2;
• the heavy chain CDR2 amino acid sequence set forth in SEQ ID NO:
• 6;
• and the heavy chain CDR3 amino acid sequence set forth in SEQ ID NO:
• 7;
• and a light chain variable region comprising the light chain CDR1 amino acid sequence set forth in SEQ ID NO:
• 20;
• the light chain CDR2 amino acid sequence set forth in SEQ ID NO:
• 21;
• and the light chain CDR3 amino acid sequence set forth in SEQ ID NO:
• 22;
• a heavy chain variable region comprising the heavy chain CDR1 amino acid sequence set forth in SEQ ID NO:
• 2;
• the heavy chain CDR2 amino acid sequence set forth in SEQ ID NO:
• 9;
• and the heavy chain CDR3 amino acid sequence set forth in SEQ ID NO:
• 10;
• and a light chain variable region comprising the light chain CDR1 amino acid sequence set forth in SEQ ID NO:
• 24;
• the light chain CDR2 amino acid sequence set forth in SEQ ID NO:
• 25;
• and the light chain CDR3 amino acid sequence set forth in SEQ ID NO:
• 26;
• or
• a heavy chain variable region comprising the heavy chain CDR1 amino acid sequence set forth in SEQ ID NO:
• 12;
• the heavy chain CDR2 amino acid sequence set forth in SEQ ID NO:
• 13;
• and the heavy chain CDR3 amino acid sequence set forth in SEQ ID NO:
• 14;
• and a light chain variable region comprising the light chain CDR1 amino acid sequence set forth in SEQ ID NO:
• 28;
• the light chain CDR2 amino acid sequence set forth in SEQ ID NO:
• 29;
• and the light chain CDR3 amino acid sequence set forth in SEQ ID NO:
• 30.