Compounds for inhibiting 1-deoxy-D-xylulose-5-phosphate reductoisomerase
AssigneesThe George Washington University, George Mason University, St. Jude Children's Research Hospital, The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsHelena I. Boshoff, Cynthia S. Dowd, Emily R. Jackson, Kylene Kehn-Hall, Richard E. Lee, Robin Lee, Geraldine San Jose
Life of this patent
Estimating the term…
Abstract
In particular, the compound is effective to inhibit Dxr in Mycobacterium tuberculosis (Mtb). The present invention relates to compounds having general formula (I) or (II) where X is an acidic group, such as carboxylate, phosphonate, sulfate, and tetrazole; Ar is a substituted or unsubstituted aromatic or heteroaromatic group; and n is 0, 1, 2, 3, or 4, preferably 2, 3, or 4. The compounds inhibits 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr), particularly Dxr in Mycobacterium tuberculosis (Mtb).
Claims9
A compound having the chemical structure of formula (II)
- wherein X is 1) a carboxylate, phosphonate, sulfate, an ester thereof, or a salt thereof, or 2) a tetrazole;
- Ar is a substituted or unsubstituted aromatic or heteroaromatic group;
- and n is 0, 1, 2, 3, or 4,
- wherein “n is 1” and
- are not simultaneously satisfied.
A compound having the chemical structure of formula (II)
- wherein X is 1) a carboxylate, phosphonate, sulfate, an ester thereof, or a salt thereof, or 2) a tetrazol;
- Ar is a substituted or unsubstituted aromatic or heteroaromatic group;
- and wherein n is 2, 3, or 4.
A compound having the chemical structure of formula (II)
- wherein X is a phosphonate, an ester thereof, or a salt thereof;
- Ar is a substituted or unsubstituted aromatic or heteroaromatic group;
- and n is 0, 1, 2, 3, or 4, wherein “n is 1” and
- are not simultaneously satisfied.
A pharmaceutical composition comprising a compound having the chemical structure of formula (II)
- wherein X is 1) a carboxylate, phosphonate, sulfate, an ester thereof, or a salt thereof, or 2) tetrazole;
- Ar is a substituted or unsubstituted aromatic or heteroaromatic group;
- and n is 0, 1, 2, 3, or 4, wherein “n is 1” and
- are not simultaneously satisfied.
A pharmaceutical composition comprising a compound having the chemical structure of formula (II)
- where X is 1) a carboxylate, phosphonate, sulfate, an ester thereof, or a salt thereof, or 2) a tetrazole;
- Ar is a substituted or unsubstituted aromatic or heteroaromatic group;
- wherein n is 2, 3, or 4.
Dependencies are inferred from the claim text.