Means and methods for treating and/or preventing natural AHR ligand-dependent cancer
AssigneeDeutschland Krebsforschungszentrum
InventorsMichael Platten, Christiane Opitz, Wolfgang Wick, Ulrike Litzenburger
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Abstract
The present invention relates to the field of cancer therapeutics and treatment of cancer. In particular, it relates to a method for treating and/or preventing a natural AHR ligand-dependent cancer comprising administering to a subject suffering from said cancer a therapeutically effective amount of an AHR inhibitor. Moreover, contemplated is a AHR inhibitor for use in treating and/or preventing a natural AHR ligand-dependent cancer.
Claims2
A method for treating a natural AHR ligand-dependent cancer comprising administering to a subject suffering from the cancer a therapeutically effective amount of an AHR inhibitor, wherein:
- (a) the natural AHR ligand is kynurenine, and
- (b) the AHR inhibitor is a flavone or derivative thereof selected from the group consisting of 3,4-dimethoxyflavone, 3′-methoxy-4′-nitroflavone, 4′,5,7-Trihydroxyflavone (apigenin), and 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyllphenyl-IH-pyrazole-5-carboxamide.
Dependencies are inferred from the claim text.