Microfluidic structure
AssigneeLandegren Gene Technology AB
InventorsJonas Sven Peter Jarvius, Jonas Melin
Life of this patent
Estimating the term…
Abstract
A microfluidic structure comprising a thermoplastic portion defining a microfluidic recess, a bonding layer on the thermoplastic portion and a siloxane elastomer portion covalently bonded to the bonding layer to seal the microfluidic recess. The microfluidic recess can therefore be formed simply, quickly and cheaply using known injection molding techniques, which are not hampered by the need for a curing step. However, the positive qualities associated with elastomers can be brought to the structure by using this to seal the microchannels. The bonding layer can be formed by silica deposited on the thermoplastic portion using techniques known in the field of optics.
Claims19
A method for forming a microfluidic structure, comprising:
- (a) providing a thermoplastic portion that comprises a microfluidic recess;
- (b) generating a layer of silica on said thermoplastic portion;
- (c) subjecting said layer of silica generated in (b) to oxidation conditions to provide an oxidized layer of silica;
- and
- (d) subsequent to (c), bringing said oxidized layer of silica in contact with an oxidized portion of poly(dimethylsiloxane) (PDMS) to covalently bond said oxidized layer of silica to said PDMS, thereby forming said microfluidic structure, wherein bonding between said oxidized layer of silica and said PDMS is stronger than a tensile strength of said PDMS.
Dependencies are inferred from the claim text.