3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide
AssigneeParion Sciences, Inc.
InventorMichael R. Johnson
Life of this patent
Estimating the term…
Abstract
The present invention relates to the compound of the formula: or pharmaceutically acceptable salts thereof, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute and chronic bronchitis, cystic fibrosis, emphysema, and pneumonia.
Claims68
A method for treating a disease selected from the group consisting of primary ciliary dyskinesia, chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute bronchitis, chronic bronchitis, post-viral cough, cystic fibrosis, emphysema, pneumonia, panbronchiolitis, transplant-associate bronchiolitis, ventilator-associated tracheobronchitis, and reversible and irreversible airway obstruction, or for preventing ventilator-associated pneumonia in a human in need thereof, said method comprising administering to said human an effective amount of a compound of formula (Ia):
- or a pharmaceutically acceptable salt thereof.
A method for treating chronic obstructive pulmonary disease (COPD) in a human in need thereof, said method comprising administering to said human an effective amount of a compound of formula (Ia):
- or a pharmaceutically acceptable salt thereof.
A method for treating cystic fibrosis in a human in need thereof, said method comprising administering to said human an effective amount of a compound of formula (Ia):
- or a pharmaceutically acceptable salt thereof.
A method for treating primary ciliary dyskinesia in a human in need thereof, said method comprising administering to said human an effective amount of a compound of formula (Ia):
- or a pharmaceutically acceptable salt thereof.
A method for treating bronchiectasis in a human in need thereof, said method comprising administering to said human an effective amount of a compound of formula (Ia):
- or a pharmaceutically acceptable salt thereof.
A method for treating a disease selected from the group consisting of primary ciliary dyskinesia, chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute bronchitis, chronic bronchitis, post-viral cough, cystic fibrosis, emphysema, pneumonia, panbronchiolitis, transplant-associate bronchiolitis, ventilator-associated tracheobronchitis, and reversible and irreversible airway obstruction, or for preventing ventilator-associated pneumonia in a human in need thereof, said method comprising administering to said human an effective amount of a compound of formula (Ia):
A method for treating cystic fibrosis in a human in need thereof, said method comprising administering to said human an effective amount of a compound of formula (Ia):
A method for treating primary ciliary dyskinesia in a human in need thereof, said method comprising administering to said human an effective amount of a compound of formula (Ia):
Dependencies are inferred from the claim text.