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US 9,580,474 B2Granted
Polyionic papilloma virus-like particle (VLP) vaccines
AssigneeThe Johns Hopkins University
InventorsRaphael Paul Viscidi, Ioannis Bossis
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Abstract
The present invention relates to the field of vaccines. In particular, the present invention provides compositions and methods relating to virus-like particle (VLP) vaccines. In one embodiment, a chimeric papillomavirus virus-like particle (VLP) comprises the L1 protein, wherein the HI loop of the L1 protein comprises negatively charged amino acids. In a more specific embodiment, a chimeric bovine papillomavirus VLP comprises the L1 protein, wherein the amino acid sequence EEEEEEEEC is inserted into the HI loop of the L1 protein.
Claims21
A vaccine comprising:
- (a) a chimeric papillomavirus virus-like particle (VLP) comprising a L1 protein, wherein an amino acid sequence EEEEEEEEC (SEQ ID NO:
- 11) is inserted into the HI loop of the L1 protein;
- and (b) a target antigen other than the L1 protein, wherein the target antigen comprises a region of positively charged amino acids, and wherein the amino acid sequence EEEEEEEEC (SEQ ID NO:
- 11) of the HI loop of the L1 protein is covalently bound to the positively charged region of the target antigen.
1 more element
Dependencies are inferred from the claim text.