Cannabinergic nitrate esters and related analogs

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof;
• wherein:
• ring C has zero, one, two or three double bonds;
• X is carbon, CH, N, NH, C(CH2)2, S, O, SO, SO2, or CF2;
• R1 is H, OH, alkyl-OH, ═O, halogen, alkyl, COOH, C(O)Oalkyl, O(CO)alkyl, nitro, ONO2, or optionally substituted alkyl, haloalkyl, alkenyl, alkynyl, acyl, aryl, heterocyclyl, heteroaryl, alkoxy, aryloxy, heteroarylalkyl, heteroalkoxy, heteroaryloxy, alkenyl, amino, thio, cyano, thiocynato, isothiocynato, carboxyl, formyl, carbamyl, amino, acylamino, amido, imido, aminoalkyl, aminoaryl, heteroarylamino, heterocyclylamino, sulfonate, sufonamide, sulfonyl, thioalkyl, thioaryl, heteroarylthio, heterocyclylthio, phosphonate, phosphate, or acetate;
• W is C(CH3)2, CH(CH3), C═O, CF2, C═S, C═CH2, spirocyclic ring, S, SO, SO2, or C[CH3(R4)];
• R4 is an optionally substituted alkyl, alkenyl, or alkynyl group;
• Z is O, S, SO, SO2, NH, or N-alkyl;
• R2 is H, OH, SH, NH2, CF3, COOH, alkoxy, halogen, ONO2, alkyl-ONO2, or optionally substituted alkyl, haloalkyl, amine, amide, imide, alkoxy, alkoxy thio, phosphate, phosphonate, carboxyl, formyl, carbamyl, amino, acylamino, amido, imido, aminoalkyl, aminoaryl, heteroarylamino, heterocyclylamino, sulfonate, sufonamide, sulfonyl, thioalkyl, thioaryl, heteroarylthio, heterocyclylthio, phosphonate, phosphate, or acetate;
• Y is a bond, C(CH3)2, CF2, C═O, CH(alkyl), C(alkyl)2, C(O)O, NHCO, CONH, alkyl, C(O)Oalkyl, OC(O)alkyl, cycloalkyl, heterocyclyl, lactone, lactam, sultam, O, S, SO, SO2, OSO2, amine, diazine, alkenyl, or alkynyl group;
• R3 is absent, or is O, S, SO2, SO2NH, NHSO2, OSO2, OSO2alkyl, C(O)Oalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, a carbocyclic, a spirocyclic, heterocyclyl, aryl, heteroaryl, carboxyl, acetate, amine, amide, or imide;
• V is V1 or ONO2, wherein when any of rings A, B or C comprises a group comprising ONO2, V is V1, otherwise V is ONO2;
• and
• V1 is H, F, Cl, Br, I, haloalkyl, N3, NCS, CN, NO2, OH, alkoxy, amino, alkylamino, dialkylamino, trialkylamino, aryl, cycloalkyl, alkyl, alkenyl, alkynyl, —C(O)aryl, —C(O)alkyl, C(O)Oalkyl, —C(O)heteroaryl, —C(O)amino, —C(O)(dialkylamino), C(O)(trialkylamino), C(O)(heterocyclyl), C(O)heteroaryl, —OC(O)alkyl, OSO2H, OSO2(alkyl), OSO2(aryl), OSO2NO2, OSO2(alkyl)CN, OSO2(alkyl)OH, OSO2alkylamino), —SC(O)alkyl, —SO2alkyl, —SO-alkyl, —SC(CH3)2C(O)Oalkyl, —SC(CH3)2C(O)Oaryl, —SC(CH3)2C(O)Oheteroaryl, —SC(CH3)2C(O)Oheterocyclyl, Si(alkyl)3, —OC(O)aryl, NHC(O)alkyl, NHC(O)aryl, —C(O)H, C(O)Oalkyl, SO2(amino), SO2(heterocyclyl), SO2(trialkylamino), SO2(dialkylamino), carbocyclic, a spirocyclic ring, heterocyclyl, heteroaryl, alkylthio, alkylamino, dialkylamino, alkylsulfinyl, alkylsulfonyl, boronic acid, boronate ester, BF3K, or a biotin group tethered via an amide bond.