Therapeutic ribonucleases

A method for treating a subject, comprising administering to a subject a composition comprising a ribonuclease having:

• i) a human RNase 1 amino acid sequence with at least 95% sequence identity to SEQ ID NO:1, ii) a cysteine at the position corresponding to position 4 of SEQ ID NO:1, iii) an arginine at the position corresponding to position 38 of SEQ ID NO:1, iv) a glycine at the position corresponding to position 39 of SEQ ID NO:1, v) an arginine at the position corresponding to position 67 of SEQ ID NO:1, vi) an arginine at the position corresponding to position 89 of SEQ ID NO:1, vii) an arginine at the position corresponding to position 90 of SEQ ID NO:1, and viii) a cysteine at the position corresponding to position 118 of SEQ ID NO:1.