Methods for treating or preventing asthma by administering an IL-4R antagonist
AssigneesSanofi Biotechnology, Regeneron Pharmaceuticals, Inc.
InventorsMarius Ardeleanu, Namita A. Gandhi, Neil Graham, Stephanie C. Kirkesseli, Sudeep Kundu, Ross E. Rocklin, Allen Radin, Steven P. Weinstein, Jennifer Davidson Hamilton, Jeffrey Ming
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Abstract
The present invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody.
Claims19
A method for the treatment of persistent asthma that reduces the incidence of asthma exacerbations or improves one or more asthma-associated parameter(s) in a subject with persistent asthma comprising sequentially administering to the subject a single initial dose of a pharmaceutical composition comprising an antibody or an antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof specifically binds an interleukin-4 receptor (IL-4R), and wherein administration of the single initial dose is followed by one or more secondary doses of the pharmaceutical composition comprising the antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof comprises heavy chain and light chain complementarity determining region (CDR) sequences from a heavy chain variable region (HCVR)/light chain variable region (LCVR) sequence pair of SEQ ID NOs:
- 162/164.
A method for the treatment of persistent asthma that reduces or eliminates an asthma patient's dependence on inhaled corticosteroids (ICS) and/or long-acting beta-agonists (LABA) for the treatment of one or more asthma exacerbations comprising:
- (a) selecting a patient with persistent asthma who has moderate-to-severe asthma that is uncontrolled with a background asthma therapy comprising an ICS, a LAB A, or a combination thereof;
- (b) administering to the patient a defined dose of an antibody or antigen-binding fragment thereof that specifically binds to an Interleukin-4 receptor (IL-4R) at a defined frequency for an initial treatment period while maintaining the patient's background asthma therapy for the initial treatment period;
- and
- (c) gradually reducing or eliminating the dosage of ICS and/or LABA administered to the patient over the course of a subsequent treatment period while continuing to administer the antibody or antigen-binding fragment thereof at the defined frequency and dose used during the initial treatment period,
- wherein the antibody or antigen-binding fragment thereof comprises heavy chain and light chain complementarity determining region (CDR) sequences from a heavy chain variable region (HCVR)/light chain variable region (LCVR) sequence pair of SEQ ID NOs:
- 162/164.
Dependencies are inferred from the claim text.