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US 9,573,918 B2Granted
Fumigillol compounds and methods of making and using same
AssigneeZafgen, Inc.
InventorsRobert Zahler, James E. Vath
Life of this patent
Estimating the term…
Abstract
The disclosure provides fumagillol type compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
Claims17
A compound represented by
- wherein
- R1 is H or C1-3alkyl;
- or pharmaceutically acceptable salts or stereoisomers thereof.
A compound represented by:
- wherein
- R2 is selected from the group consisting of hydroxyl and isopropyl (optionally substituted with a hydroxyl);
- R3 is selected from the group consisting of H, and hydroxyl;
- or pharmaceutically acceptable salts or stereoisomers thereof.
1 more element
A compound represented by:
- wherein
- R4 and R5, together with the nitrogen to which they are attached, form a 4 membered ring optionally substituted by one or two substituents independently selected from the group consisting of methyl and hydroxyl;
- or pharmaceutically acceptable salts or stereoisomers thereof.
A compound represented by
- wherein
- n is 1 or 2;
- or pharmaceutically acceptable salts or stereoisomers thereof.
A compound selected from the group consisting of:
- and pharmaceutically acceptable salts or stereoisomers thereof.
A compound selected from the group consisting of:
- and pharmaceutically salts or stereoisomers thereof.
Dependencies are inferred from the claim text.