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US 9,572,771 B2Granted
Pharmaceutical composition and use
AssigneeSpineThera
InventorJeff Missling
Life of this patent
Estimating the term…
Abstract
An injectable, flowable composition, kits that include the same, and methods of medical treatment of a mammal (e.g., human) that include the administration of the same are provided.
Claims13
A method for the treatment of back pain, the method comprising injecting an injectable, flowable composition into the epidural space, the composition comprising:
- (a) microparticles comprising an anti-inflammatory agent and a polymer, wherein the microparticles have a d90 of less than about 7 μm, wherein the polymer comprises a block copolymer of lactic acid and glycolic acid (PLGA) and polyethylene glycol (PEG), and the anti-inflammatory agent is present in a weight of up to about 40% the weight of the polymer and wherein the surface of the microparticles is hydrophilic;
- and
- (b) a hydrophilic, liquid carrier vehicle;
- wherein the microparticles are substantially miscible to dispersible in the liquid carrier vehicle.
1 more element
A method for the treatment of back pain, the method comprising injecting no more than once per about 2 weeks an injectable, flowable composition having a total volume of less than about 20 mL into the epidural space, the composition comprising:
- (a) microparticles comprising an anti-inflammatory agent and a polymer, the microparticles have a d90 of less than about 7 μm the polymer comprises a block copolymer of lactic acid and glycolic acid (PLGA) and polyethylene glycol (PEG), and the anti-inflammatory agent is present in a weight of up to about 40% the weight of the polymer and wherein the surface of the microparticles is hydrophilic;
- and
- (b) a hydrophilic, aqueous liquid carrier vehicle;
- wherein the microparticles are substantially miscible to dispersible in the liquid carrier vehicle.
1 more element
Dependencies are inferred from the claim text.