Microorganisms and methods for producing substituted phenols
AssigneeSymrise AG
InventorsStefan Lambrecht, Jens-Michael Hilmer, Manuel Pesaro, Jens Kroll, Gunda Hansen, Alexander Steinbüchel, Christian Fleige
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Abstract
The present invention is concerned with methods for producing vanillin, feroyl-CoA, ferulic acid, coniferyl aldehyde and/or coniferyl alcohol. Also, the invention relates to microorganisms useful in such production method, and to the construction of such microorganisms.
Claims15
A method for producing a product selected from the group consisting of vanillin, feruloyl-CoA, ferulic acid, coniferyl aldehyde and coniferyl alcohol, comprising adding an educt selected from the group consisting of eugenol, coniferyl alcohol, coniferyl aldehyde and ferulic acid to a microorganism of order Actinomycetales and genus Amycolatopsis, wherein the microorganism does not comprise a gene coding for a vanillin dehydrogenase having at least 90% sequence similarity with SEQ ID NO 1, 2, or 3, or comprises an inactivated vanillin dehydrogenase gene having at least 90% sequence similarity with SEQ ID NO 1, 2, or 3.
A microorganism of order Actinomycetales and genus Amycolatopsis, wherein the microorganism does not comprise a gene coding for a vanillin dehydrogenase having a sequence with 90% sequence similarity with SEQ ID NO 1, 2, or 3, or microorganism comprises an inactivated vanillin dehydrogenase gene having at least 90% sequence similarity with SEQ ID NO 1, 2, or 3.
Dependencies are inferred from the claim text.