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US 9,567,616 B2Granted
Process for producing target substance by fermentation
AssigneeKyowa Hakko Bio Co., Ltd.
InventorsTetsuro Ujihara, Tetsuya Abe, Makoto Yagasaki
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Abstract
A target substance can be efficiently produced by culturing, in a medium, a coryneform bacterium in which the activity of a PTS protein relating to fructose uptake is reduced or lost as compared with a parent strain and the bacterium can produce the target substance, allowing the target substance to form and accumulate in a culture; and collecting the target substance from the culture.
Claims8
A process for producing a target substance, comprising:
- culturing in a medium that contains glucose as a sole carbon source a coryneform bacterium in which the activity of both FruK protein and FruA protein are lost as compared with a parent strain, wherein the bacterium can produce the target substance;
- allowing the target substance to form and accumulate in a culture;
- and
- collecting the target substance from the culture, wherein
- the target substance is an amino acid, a peptide or a protein.
2 more elements
Dependencies are inferred from the claim text.