Oligonucleotide—containing pharmacological compositions and their use

A composition suitable for oral administration to a mammal suffering from a pathological disorder or disease comprising a first and a second modified oligonucleotide, wherein

• (a) said first and said second modified oligonucleotide each comprise about seven to seventy-five nucleotides containing seven or more contiguous ribose groups linked by achiral 5′ to 3′ internucleotide phosphate linkages, wherein said ribose groups of said modified oligonucleotides have a 2′ modification, and wherein the 5′ and/or 3′ ends of said modified oligonucleotides are blocked;
• (b) said first modified oligonucleotide is complementary to a region of a first gene associated with said pathological disorder or disease and said second modified oligonucleotide is complementary to a region of a second gene associated with said pathological disorder or disease, wherein the nucleotide sequence of said first modified oligonucleotide comprises SEQ ID NO:1 and the nucleotide sequence of said second modified oligonucleotide comprises SEQ ID NO:6;
• and
• (c) wherein said pathological disorder or disease comprises inflammation.