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US 9,567,337 B2Granted
Process methods for phosphatidylinositol 3-kinase inhibitors
OwnerStacy Bremner, Jerry Evarts +3inventors
InventorsStacy Bremner, Jerry Evarts, Keiko Sujino, Duong Tran, Dragos Vizitiu
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Abstract
A process for the synthesis of quinazolinone containing compounds which may be useful for the treatment of cancer, is hereby disclosed. In addition, compound intermediates relating to these processes are also disclosed.
Claims44
A process comprising step a) combining a compound of formula 9
- or a salt thereof,
- and a compound of formula 10
- wherein a compound of formula 8:
- or a salt thereof, is synthesized;
- and
- step b) combining the compound of formula 8 or a salt thereof and aniline, wherein a compound of formula 11:
- or a salt thereof is synthesized.
4 more elements
A process comprising step a) combining a compound of formula 16:
- or a salt thereof,
- and a compound of formula 10a:
- wherein a compound of formula 15:
- or a salt thereof, is synthesized;
- and
- step b) combining the compound of formula 15 or a salt thereof and aniline, wherein a compound of formula 17:
- or a salt thereof is synthesized.
4 more elements
Dependencies are inferred from the claim text.