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US 9,557,635 B2Granted
Ionizing-radiation-responsive compositions, methods, and systems
AssigneeGearbox, LLC
InventorsEdward S. Boyden, Roderick A. Hyde, Muriel Y. Ishikawa, Edward K. Y. Jung, Nathan P. Myhrvold, Clarence T. Tegreene, Thomas A. Weaver, Charles Whitmer, Lowell L. Wood, Jr., Victoria Y. H. Wood
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Abstract
A method, composition and system respond to ionizing radiation to adjust biological activity. In some approaches the ionizing radiation is X-ray or extreme ultraviolet radiation that produces luminescent responses that induce biologically active responses.
Claims26
An ionizing-radiation-responsive composition, comprising:
- a luminescent material, the luminescent material being responsive to ionizing radiation to produce optical energy in at least one wavelength band;
- a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one wavelength band;
- and
- a matrix material disposed to at least partially sustain proximity of the luminescent material and the photosensitive biologically active material
- wherein the matrix material includes an optically-inhibiting material disposed to at least partially block coupling of optical energy in the at least one wavelength band to the photosensitive biologically active material.
2 more elements
An ionizing-radiation-responsive composition, comprising:
- a luminescent material, the luminescent material being responsive to ionizing radiation to produce optical energy in at least one wavelength band;
- and
- a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one wavelength band;
- and
- a coating material of a type selected to adjust at least one of the solubility, durability, suspension stability, bioactivity, biocompatibility, and non-toxicity of the ionizing-radiation-responsive composition;
- wherein the coating material is disposed in a layer that at least partially encloses the photosensitive biologically active material;
- and
- wherein the coating material includes an optically-inhibiting material disposed to at least partially block coupling of optical energy in the at least one wavelength band to the photosensitive biologically active material.
5 more elements
An ionizing-radiation-responsive bound composition, comprising:
- a luminescent material, the luminescent material being responsive to ionizing radiation to produce optical energy in at least one wavelength band;
- and
- a photosensitive biologically active material, the photosensitive biologically active material being responsive to optical energy in the at least one wavelength band;
- and
- an optically-inhibiting material disposed to selectively block coupling of optical energy in the at least one wavelength band to the photosensitive biologically active material from sources other than the luminescent material.
2 more elements
Dependencies are inferred from the claim text.