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AssigneeAthenex, Inc.
InventorsDavid G. Hangauer, Jr., Debasis Patra, Jeremy A. Cody, Grant J. Palmer, Paul K. Isbester, Jonathon Salsbury
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The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.
A polymorph of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide di-HCl salt, characterized by an X-ray powder diffraction pattern including peaks at about 15.6, 22.7, and 23.5 degrees 2θ.
A polymorph of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide di-HCl salt, characterized by an X-ray powder diffraction pattern including peaks at about 15.6, 17.0, 19.3, 21.8, 22.7, 23.5, 24.6, 26.0, 27.6, and 28.8 degrees 2θ.
A polymorph of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide di-HCl salt, characterized by an X-ray powder diffraction pattern substantially similar to that set forth in FIG. 13.
Dependencies are inferred from the claim text.