Silylation of aromatic heterocycles by disilanes using potassium alkoxide catalysts
AssigneeCalifornia Institute of Technology
InventorsAnton Toutov, Wenbo Liu, Brian M. Stoltz, Robert H. Grubbs, Kerry Betz, David P. Schuman
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Abstract
The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates, said system consisting essentially of a mixture of (a) at least one organodisilane and (b) at least alkoxide base, preferably a potassium alkoxide base, and said methods comprising contacting a quantity of the organic substrate with a mixture consisting essentially of (a) at least one organodisilane and (b) at least one alkoxide base, preferably a potassium alkoxide, under conditions sufficient to silylate the heteroaromatic substrate.
Claims46
A method comprising contacting an organic substrate having a heteroaromatic moiety with a mixture comprising (a) at least one organodisilane and (b) at least one potassium alkoxide base, in the presence of an organic solvent having an oxygen donor group, under conditions sufficient to silylate the substrate, the method resulting in a heteroaromatic silylated product.
A composition comprising:
- (a) an organic substrate comprising a heteroaromatic moiety and a silylated derivative thereof, said silylated derivative having a C—Si bond in a position corresponding to a position in the heteroaromatic moiety of the organic substrate having a C—H bond;
- (b) at least one organodisilane;
- and
- (c) at least one potassium alkoxide base.
Dependencies are inferred from the claim text.