Pulmonary delivery particles comprising an active agent
AssigneeNovartis AG
InventorsThomas E. Tarara, Jeffrey G. Weers, Alexey Kabalnov, Ernest G. Schutt, Luis A. Dellamary
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Abstract
A pulmonary delivery medicament comprises a plurality of particulates, the particulates comprising a structural matrix and a water insoluble and/or crystalline active agent. The particulates have a geometric diameter of 0.5 to 50 μm. The water insoluble active agent can be a fungicide, antibiotic, budesonide. A method of making the medicament comprises forming a liquid feedstock, and forming a feedstock suspension by suspending in the liquid feedstock, the active agent and an excipient capable of forming a structural matrix, such as a phospholipid. The feedstock suspension is spray dried to produce the particulates.
Claims18
An inhaleable powder composition comprising a plurality of particulate microstructures, the particulate microstructures comprising:
- (a) a structural matrix comprising phospholipid, wherein the particulate microstructures comprise greater than 10% phospholipid;
- (b) an active agent, wherein the particulate microstructures comprise greater than 50% active agent and wherein the active agent comprises an antibiotic;
- (c) residual amounts of a blowing agent, wherein the blowing agent comprises a fluorinated compound having a boiling point greater than 80° C., and wherein the residual amounts are 5% w/w or less;
- and
- (d) a mean aerodynamic diameter of less than 5 microns and a mean geometric diameter of less than 5 microns.
An inhaleable powder composition comprising a plurality of particulate microstructures, the particulate microstructures comprising:
- (a) a structural matrix comprising phospholipid, wherein the particulate microstructures comprise greater than 10% phospholipid;
- (b) an active agent, wherein the particulate microstructures comprise greater than 50% active agent and wherein the active agent comprises an antibiotic;
- (c) residual amounts of a blowing agent, wherein the blowing agent comprises a fluorinated compound having a boiling point greater than 80° C., and wherein the residual amounts are 5% w/w or less;
- (d) residual amounts of a moisture, wherein the residual amounts are less than 6% w/w and wherein the moisture comprises water;
- and
- (e) a mean aerodynamic diameter of less than 5 microns.
Dependencies are inferred from the claim text.