Back to results
US 9,550,836 B2Granted
Method of detecting human matrix metalloproteinase 9 using antibodies
AssigneeGilead Biologics, Inc.
InventorsVictoria Smith, Scott McCauley
Life of this patent
Estimating the term…
Abstract
The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).
Claims9
A method of detecting human MMP9 in a sample, comprising:
- a) contacting the sample with an antibody or antigen-binding fragment thereof comprising a heavy chain variable (VH) region and a light chain variable (VL) region wherein the heavy chain variable region comprises a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:
- 34, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:
- 35, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:
- 36;
- wherein the light chain variable region comprises a CDR1 comprising the amino acid sequence set forth in SEQ ID NO:
- 37, a CDR2 comprising the amino acid sequence set forth in SEQ ID NO:
- 38, and a CDR3 comprising the amino acid sequence set forth in SEQ ID NO:
- 39;
- and,
- b) detecting binding of the antibody or antigen-binding fragment thereof to human MMP9 in the sample, thereby detecting the presence or absence of the human MMP9.
7 more elements
Dependencies are inferred from the claim text.