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US 9,550,779 B2Granted
Derivatives and methods of treating hepatitis B infections
AssigneeNovira Therapeutics, Inc.
InventorsGeorge D. Hartman, Scott Kuduk
Life of this patent
Estimating the term…
Abstract
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
Claims17
A compound of Formula III:
- or a pharmaceutically acceptable salt thereof, wherein
- Y is —C(O)—;
- R1 is C6-C12-aryl or C1-C9-heteroaryl wherein aryl and heteroaryl are optionally substituted with 1 or 2 groups each independently selected from —OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, C1-C6-alkyl-OH, CN, and C(O)H;
- R2 is, at each occurrence, independently selected from H, —OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH, provided that at least one R2 is selected from —OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
- R3 is selected from H, —OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
- R4 is selected from
- and
- R7 is selected from H, C1-C6-alkyl, and C1-C6-alkyl-OH.
5 more elements
Dependencies are inferred from the claim text.