Method for synthesizing radiopharmaceuticals using a cartridge

A method for synthesizing a radiopharmaceutical using a polymer-filled cartridge, comprising:

• passing a radioisotope solution through the polymer-filled cartridge to trap a radioisotope;
• loading a reaction solution to the cartridge which comprises a solution of a precursor and/or phase transfer catalyst dissolved in solvent;
• labeling a precursor with the radioisotope entrapped by the cartridge;
• and
• eluting a radioisotope-labeled compound from the cartridge to provide the radiopharmaceutical,
• wherein the cartridge is filled with a polymer and has a structure in which an upper porous frit and a lower porous frit are placed, said polymer being located between the upper and the lower porous frit, the structure having a space over the location of the polymer and wherein the upper porous frit and the lower porous frit are not permeated with the polymer filled within the cartridge, but are permeated with a solution, wherein the polymer has a structure represented by the following Chemical Formula 1-1 or 1-2:
• wherein,
• ‘support’ is a non-soluble organic polymer selected from the group consisting of polystyrene, polyethylene glycol, and a combination thereof, or a non-soluble silica;
• ‘spacer’ is a halogen-substituted or unsubstituted hydrocarbon of C1-30 in which at least one element selected from the group consisting of nitrogen, oxygen and sulfur may be intermediated;
• ‘Y’ is a halogen-substituted or unsubstituted organic salt selected from among —NR1R2R3 or an imidazolium salt
• a triazolium salt
• and a pyridinium salt
• wherein R1, R2, and R3, are independently a hydrocarbon of C1-30 in which at least one element selected from the group consisting of nitrogen, oxygen and sulfur may be intermediated;
• ‘X’ is tetrafluoroborate (BF4), hexafluorophosphate (PF6), hexafluoroantimony (SbF6), bis(trifluoromethane)sulfone imide (N(Tf)2), potassium carbonate (KCO3), bicarbonate (HCO3), potassium phosphate (KHPO4 or K2PO4), or alkane sulfonate (R1SO3), wherein R1 is a hydrocarbon of C1-30 in which at least one element selected from the group consisting of nitrogen, oxygen, sulfur, phosphorous and a combination thereof may be intermediated;
• ‘W’ is phosphate (—PO3), carboxylate (—CO2), or sulfonate (—SO3);
• and
• ‘Z’ is hydrogen, lithium (Li), sodium (Na), potassium (K), rubidium (Rb), cesium (Cs), or quaternary ammonium salt of —NR1R2R3, wherein R1, R2 and R3 are halogen-substituted or unsubstituted, and independently a hydrocarbon of C1-30 in which at least one element selected from the group consisting of nitrogen, oxygen and sulfur may be intermediated.