Regeneration of antimicrobial coatings containing metal derivatives upon exposure to aqueous hydrogen peroxide
AssigneeQuick-Med Technologies, Inc.
InventorsWilliam Toreki, Rustom S. Kanga
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Abstract
This invention relates to regenerable antimicrobial coatings with long-lasting efficacy for use in medical applications including implants, medical instruments or devices, and hospital equipment. The same coatings would also have broad utility in the consumer, industrial, and institutional markets. The coating technology would be based on sequestration of hydrogen peroxide (HP) by zinc oxide binders incorporated into the coatings.
Claims23
A method of enhancing and regenerating durable antimicrobial activity of the surface of an article, wherein said method comprises the steps in sequence of:
- a. providing, on the surface of an article on which durable antimicrobial activity is desired, a polymer doped with a metal derivative,
- b. exposing the polymer doped with a metal derivative to a source of aqueous hydrogen peroxide for a time sufficient to permit an antimicrobially-enhancing amount of hydrogen peroxide to be sequestered thereon, and thereafter,
- c. removing the source of aqueous hydrogen peroxide,
- wherein said metal derivative comprises 1% to 50% (w/w) of the weight of the doped polymer, wherein said metal derivative is a hydroxide, an oxide, or a peroxide of a metal selected from the group consisting of zinc, magnesium, titanium, and zirconium,
- wherein the water absorbency of said polymer is between 0.5% and 20% (w/w), wherein said polymer doped with said metal derivative has been determined to be capable of sequestering hydrogen peroxide when exposed to said source of aqueous hydrogen peroxide;
- whereby said antimicrobial activity, when tested using ASTM Standard Method E2180 at least 24 hours after said removal of the source of hydrogen peroxide, provides at least a 3-log reduction of viable Escherichia coli bacteria greater than that of a corresponding surface of said polymer doped with said metal derivative which has not been exposed to hydrogen peroxide.
A regenerable antimicrobial coating comprising,
- a. a metal derivative, wherein said metal derivative is a hydroxide, an oxide, or a peroxide of a metal selected from the group consisting of zinc, magnesium, titanium, and zirconium,
- b. a polymer, wherein said polymer is doped with 1% to 50% (w/w) of said metal derivative,
- c. sequestered hydrogen peroxide,
- wherein the water absorbency of said polymer is between 0.5% and 20% (w/w), wherein said polymer doped with said metal derivative has been determined to be capable of sequestering hydrogen peroxide when exposed to said source of aqueous hydrogen peroxide;
- wherein the antimicrobial activity of said doped polymer can be regenerated on subsequent exposure to aqueous hydrogen peroxide,
- whereby said antimicrobial coating, when tested using ASTM Standard Method E2180 at least 24 hours after preparation, provides at least a 3-log reduction of viable Escherichia coli bacteria greater than that of a corresponding coating which has not been exposed to hydrogen peroxide.
Dependencies are inferred from the claim text.